Abstract
The distribution of T-3262 (tosufloxacin tosilate) was measured in New Zealand White rabbits after oral administration at a dose of 20 mg/kg.
T-3262 was detected in plasma, tongue, gingiva, submandibular gland, parotid gland, cervical lymph node and mandibular bone.
Pharmacokinetic parameters were caliculated from mean plasma levels and each tissue level by one compartment model and moment analysis.
The peak concentration of T-3262 was 4.54μg/ml in submandibular, 1.22μg/ml in parotid gland, 1.37μg/ml in cervical lymph node.
