Abstract
With patients who were to undergo tonsillectomy as subjects, a preoperative study was made of the flora and the composition of bacterial species on the surface tonsil and in the tonsil core. Bacterial content of blood immediately after the tonsillectomy was also examined. The results of the study were compared by dividing the subjects into the following three groups: non-treatment group, clindamycin phosphate (CLDM-P) group, and aminobenzyl penicillin (ABPC) group.
1) The species on the surface tonsil were all those that constitute oral flora. At the species level, aerobic bacteria and anaerobic bacteria were equal in number.
2) The number of bacteria on the surface tonsil was significantly less in the preventively administered CLDM-P group and ABPC group than in the non-treatment group.
3) The ratio of positive bacterial blood culture was 56.9% for the non-treatment group, 19.5% for the CLDM-P group, and 46.9% for the ABPC group. The reduction was significant in the CLDM-P group.
4) The distribution of CLDM and ABPC in the blood and the tonsil core differed greatly. The tonsil core level 2 hours after administration was 15.1μg/g for CLDM and 0.88μg/g for ABPC. These findings suggest that selection of drugs is also important in the preventive administration.
5) It was pointed out that problems relating to the preventive administration of antibiotics is one of the important issues confronting the modern medicine.
