Abstract
Objective : For the evaluation of the usefulness of Cefuroxime axetil (CXM-AX), a new oral Cephem antibiotic, in the field of Oral Surgery, oral tissue levels of CXM were determined and pharmacokinetic analysis was carried out.
Method : CXM-AX in the dose of 30mg/kg was orally given to a total of 18 W istar strain rats (in 6 groups, each consisting of 3) through a gastric tube. Samples were taken at 15mins, 30 mins, lhr, 2hrs, 4hrs, and 6hrs after administration. In addition to the oral tissue samples from gingiva, tongue, mandibular bone, cervical lympho node and submandibular gland, serum, liver, and kidney samples were also taken for comparison. CXM levels were determined by bioassay, and a paper disc method was adopted using Bacillus subtilis ATCC 6633 as a test organism.
Results : In serum, Tmax was 1.0 hr, Cmax, 6.95μg/ml and AUC, 24.93μg/hr/ml. When the tissue levels were compared among organs based on Cmax, the level was the highest in the kidney, and then in the descending order of liver, serum, cervical lymphonode, submandibular gland, tongue, gingiva and mandibular bone. The ratios of the above tissue levels to serum level were 1.62, 1.35, 0.78, 0.62, 0.50, 0.42 and 0.27, respectively.
