Abstract
Flomoxef Sodium (FMOX), a new oxacephem antibiotic, was preoperatively administrated by i.v. drip infusion at a dose of 2 g for half hours in patients with cyst formation in the jaw. Then the consentration of FMOX in serum, jaw bone, cyst wall or cyst like structure in the jaws, and its content, all collected during operation, were examined. Moreover, the pharmacokinetic analysis using compartment model was performed, and following result were obtained :
1. Peak levels of FMOX in serum, bone, cyst wall and its content were 122.30, 16.72 41.08, 8.48μg/ml, respectively, and the time of peak level were 0.5, 0.62, 0.61, 1.89 hours, respectively.
2. The half life of FMOX (β-phase) were 1.35, 1.35, 1.35, 2.08 hours, respectively.
3. The AUC values of FMOX were, 149.0, 27.4, 66.0, 52.9μg.h/ml, respectively.
