Abstract
Treatment goal and management of infantile bronchial asthma described in JPGL 2005 were weighed against the relevant parts in GINA 2006 and NAEPP EPR3. JPGL 2005 recommends starting anti-inflammatory therapy from the earlier stage than these international guidelines, however, the reality of the treatment in Japan has not followed it. Although the secondary prevention effect by an administration of the inhaled steroid reported a negative result in 2006, an ideal early intervention was proposed by reviewing these study protocols and results in details. The ideal early intervention by anti-inflammatory treatment, which the mainstream is an inhaled corticosteroid, seems to increase the possibilities of modifying a natural history of asthma, and further investigation is necessary to examine the hypothesis in the future. Also this report reviewed genetic and environmental factors related to the onset of disease and the long-term prognosis, and actions to be taken near future for an infantile asthma treatment were summarized at last.
