TWO CASE REPORTS OF NON-IGE-MEDICATED COW'S MILK ALLERGY MIMICKING INFANTILE HEPATITIS

Abstract

Two patients with hypersensitivity against cow's milk who presented with elevated serum AST, ALT and CRP levels. Neither non-specific IgE level nor cow's milk-specific IgE was not elevated. Since infancy, they had been suffered from recurrent fever and diarrhea. Lymphocyte proliferative responses for α-casein and cow's milk formula were positive. Their symptoms and serum AST, ALT and CRP levels were normalized by changing the fomula from cow's milk to an amino acid fomula.
In conclusion, features of mimicking infantile hepatitis in these cases may be due to type IV hypersensitivity reaction to cow's milk proteins.