FOOD PROTEIN-INDUCED ENTEROCOLITIS SYNDROME (FPIES), CASE-SERIES STUDY AND CONSENSUS RECOMMENDATIONS FOR DIAGNOSIS AND TREATMENT

Abstract

In Japan, the number of reported cases of food protein-induced enterocolitis syndrome (FPIES) has increased dramatically since 1995. IgE is not generally required for the pathogenesis, and the absence of detection of milk-specific IgE antibodies often makes diagnosis difficult. If diagnosis and treatment of FPIES are delayed, ileus and impaired development can occur. Therefore, Japanese Research Group for Neonatal, Infantile Allergic Disorders has established guidelines to enable prompt diagnosis and treatment of FPIES. We will show here our Consensus Recommendations for Diagnosis and Treatment and on-going research data for making definite diagnostic method.