Abstract
Bioactive lipid mediators such as prostaglandins, thromboxanes and leukotrienes play significant roles as modulators in pathogenesis of inflammatory, allergic and neoplastic diseases. These bioactive substances are synthesized through an activation of a series of synthesizing enzymes. The production of these substances is primarily regulated by different distribution of synthesizing enzymes. In addition, new induction of synthesizing enzymes at mRNA levels by external and/or internal stimulation has been elucidated as another important mechanism regulating production of these lipid mediators.
