Abstract
There is a dramatically increase in the prevalence of allergic diseases, which is now referred as so-called National Disease. To clarify risk factors related with the development of allergic diseases and then to prevent and alleviate allergic diseases is very important issues. It can lead to expand national health and to reduce both medical expenses and costs of social security. Allergic diseases may be primed in the uterus and they develop at the time of infants and younger children, being referred to as allergic march. Pediatricians should take care of this issue, because they just examine infants and younger children.
Performing birth-cohort studies of great precision should be needed to clarify the risk factors native to Japan related with development of allergic diseases. Younger children with higher risk factors may be selected and introduced to primary prevention. In this paper, we presented our data we have recently performed birth cohort study, and discussed the primary prevention of allergic diseases, which should be performed during pregnancy at which fetuses are primed towards allergic status, especially from an epigenetics point of view.
