Abstract
Allergen-specific immunotherapy has been considered as only one treatment to change the natural course of allergic diseases. For the management of childhood asthma, however, the indication of immunotherapy is limited to small numbers of well-controlled patients and its therapeutic effects could be little, if any, under treatment with asthma controllers, including inhaled corticosteroid. Commencement of immunotherapy from early childhood is indispensable to prevent the development of asthma. Although the current allergen-specific immunotherapy seems useful for the treatment of pollinosis, considering the risk of severe systemic side effects, it is not essential for the management of childhood asthma.