Abstract
Fundamental principle for patients with allergic disease is to avoid the exposure to allergen. Elimination diet is the practical method in the case of food allergy. However, immunosuppression to the antigen orally ingested (and absorbed through the intestinal mucosa) has been recognized for a long time in the area of immunology, the concept being established as oral tolerance. In recent years, the information that oral tolerance functions in human model, and that sensitization occurs through the skin with impaired barrier function, came to our knowledge, and a new maneuver, which is quite different from the conventional method, has come into view. Delayed weaning may precipitate food allergy, and the optimal weaning schedule to prevent food allergy should be investigated.
