2016 Volume 30 Issue 5 Pages 651-658
1 : Exhaled nitric oxide concentration (eNO) is measured by handle device with expiratory flow rate of 50 ml/s and eNO plateau of 3 seconds according to ATS/ERP recommendation for standardized procedures. 2 : eNO values can be affected by several factors, including sex, age, height and atopic status. ATS recommended the use of cut points rather than reference values classified into low, intermediate and high eNO in children and adults. 3 : In case of asthmatic children, high eNO predicts effectiveness of ICS therapy for clinical and spirometric improvement. On the other side, low eNO suggests non-eosinophilic inflammation and poor ICS responsiveness. 4 : Some asthma phenotypes, such as mild atopic asthma, atopic asthma with allergic rhinitis dominant and severe atopic asthma with small airway obstruction were defined by our studies using eNO, lung function test and total and specific IgE analysis in asthmatic children older than 12 years of age, 5 : eNO is one of the Th2 high biomakers and its measurement is not only simple and non-invasive but also can be playfully performed, so eNO may be one of most expecting Th2 high biomarkers for predicting responsiveness of biologic medications in near future.
