A prolonged cough treatment strategy “prolonged cough and airway secretion”

Abstract

 Airway secretion is essential for the maintenance of normal respiration, but hypersecretion gives rise to various negative effects, including impaired mucociliary clearance, which leads to prolonged cough. Asthmatic patients with chronic cough and sputum are known to exhibit poor disease control and more frequent exacerbations. For those patients, essential treatments to control airway inflammation are insufficient, and strategies that directly target airway secretion are also important. Treatment for hypersecretion includes ①suppression of mucin production, ②inhibition of mucin secretion, and ③promotion of mucociliary clearance.