Asthma management for preschool childhood asthma

Abstract

 I described asthma management for asthma in preschool children. 1) The phenotype of preschool children asthma was classified into IgE-related asthma (allergen-induced asthma/atopic asthma) and non-IgE related asthma (virus induced asthma etc.). 2) “Diagnostic treatment” was used for the diagnosis of preschool asthma. 3) In preschool asthma, most of IgE-related asthma shifts to “atopic asthma” which is positive for inhalation allergens. On the other hand, a part of non-IgE-related asthma shifts to “atopic asthma” or “non-atopic asthma”. 4) The transition from preschool asthma to refractory asthma is the two phenotypes of multiple antigen positive atopic asthma and neutrophilic asthma with pulmonary function decline. 5) To prevent the transition to intractable asthma, early intervention in preschool asthma is necessary. Salmeterol・fluticasone combination (SFC) is considered effective for prevention of neutrophilic asthma accompanied by decreased pulmonary function at school age. And prevention of multiple antigen positive atopic asthma, Sublingual immunotherapy for cedar and mite is considered useful.