2020 Volume 34 Issue 5 Pages 543-550
Objective: To clarify the risk factors for systemic reactions (SRs) during rapid induction phase in rush subcutaneous immunotherapy with standardized house dust mite extract (HDM-SCIT).
Methods: In 68 cases who were introduced with the rush subcutaneous immunotherapy with standardized house dust mite antigen (HDM-rSCIT), we examined the risk factors for SRs such as age, threshold and starting antigen dose of HDM, target antigen dose of HDM in rapid induction phase, season of introduction, coexistence of allergic disease, and the severity of bronchial asthma and allergic rhinitis.
Results: The SRs of HDM-rSCIT appeared in 44 of 68 cases (65%), and the risk factors for the SRs were 500JAU of target HDM antigen dose in rapid induction phase, introduction other than summer, and high allergic rhinitis symptom medication score.
Conclusion: It was suggested that the SRs may be decreased by strictly managing the symptoms of allergic rhinitis before introduction, reducing the target HDM antigen dose in rapid induction phase, and introducing SCIT in summer.
