Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology
Online ISSN : 1882-2738
Print ISSN : 0914-2649
ISSN-L : 0914-2649
Passive smoking and allergic diseases in childhood: a systematic review
Masanori IkedaTomonobu KikkawaSeigo KorematsuSyuichi SuzukiAkihiko TeradaYosuke Fujii
Author information
Supplementary material

2021 Volume 35 Issue 2 Pages 152-169


A systematic review was conducted to examine epidemiological and other medical findings regarding 8 clinical questions to investigate associations between passive smoking and allergic diseases in childhood. Passive smoking was associated with the following in childhood: increased risk of onset, aggravation, and impaired respiratory function in asthma; increases in coughing and sputum. Maternal smoking during pregnancy was associated with onset of asthma in childhood, and persistent impairment of respiratory function from birth. Passive smoking was suggested as a risk factor associated with onset and aggravation of allergic rhinitis, and was also associated with increases in total IgE levels and positive specific IgE test and skin prick test results. In particular, passive smoking during early infancy was significantly associated with sensitization to food and indoor allergens. Reported studies on atopic dermatitis and food allergies were limited, and findings on their associations with passive smoking were contradictory. Thus, their causal relationship was inconclusive in this study. In sum, passive smoking has serious impacts on allergic diseases in childhood and proactive avoidance of passive smoking is recommended.

Content from these authors
© 2021 Japanese Society of Pediatric Allergy and Clinical Immunology
Previous article Next article