Japanese cedar pollinosis and fruit allergy caused by GRPs

Abstract

Cedar (Cryptomeria japonica) pollinosis is one of the most common allergic diseases in Japan. Cedar pollen contains several allergens, including gibberellin-regulated protein (GRP). GRPs are widely conserved proteins in plants and have been reported as fruit allergens, including Pru p 7, which was identified in peach fruit, causing mainly oral symptoms and in some cases systemic allergic symptoms.

We recently reported that one of the causes of fruit allergy in cypress pollinosis patients is the development of pollen-food allergy syndrome (PFAS) caused by GRPs, Cup s 7 from European cypress (Cupressus sempervirens) pollen and Cry j 7 Japanese cedar (C. japonica) pollen.

In this paper, we review the allergen studies of GRP, including PFAS.