Chapter 1: Methodology of JGFA2021 and CQs

Abstract

The Japanese Guidelines for Food allergy (JGFA) 2021 has been revised five years after the previous edition and is based on the policy of Medical Information Network Distribution Service. The JGFA was developed by a three-tiered organizing committee. The committee finalized the scope of the JGFA and selected four clinical questions (CQ) on oral immunotherapy and oral food challenge test based on the key clinical issues. Systematic reviews on two CQs on oral immunotherapy were conducted by referring to the relevant Cochrane review, and those on two CQs on oral food challenge test were conducted including observational studies. The results were reviewed by each outcome, and the total body of evidence was evaluated along with the bias. The recommendations were determined by a confidential ballot of all committee members. Each recommendation on the JGFA is included with a commentary.