2023 Volume 37 Issue 1 Pages 99-104
We experienced two cases with anaphylactic symptoms after ingestion of macadamia nuts. In case 1, a moisturizer containing macadamia nut oil was used for a year before the onset of symptoms. Thus, skin sensitization was suspected. In both cases, prick-to-prick test with roasted macadamia nuts were positive. Antigenic protein of macadamia nuts was extracted and reacted with the patient's serum by immunoblotting, detecting positive bands around 20kDa, 50 kDa, 60kDa, and 65 kDa in case 1, as well as around 18kDa, 20 kDa, 50 kDa, 60kDa in case 2. As what we know of, no IgE binding has been reported for the 60kDa, 65 kDa protein in previous studies. The involvement of skin sensitization should be investigated by further identification of macadamia nut antigenic proteins and components, as well as analysis of oil components.
