2025 Volume 39 Issue 1 Pages 24-31
【Background】Food protein-induced enterocolitis syndrome (FPIES) incidence has recently increased worldwide. In this study, we elucidated the clinical features of FPIES.
【Method】We enrolled patients who met the international consensus diagnostic criteria among pediatric patients suspected of FPIES for 13 years. We retrospectively analyzed the offending foods, clinical results, and clinical course.
【Results】We included 35 patients in this study. Vomiting was the most frequent symptom (100%), followed by lethargy, pallor, and diarrhea. One patient reacted to multiple triggers. We identified 36 offending foods, hen's egg was the most common (21 cases). Although all cases of hen's egg reacted to that egg yolk, none reacted only to egg white. FPIES case numbers, especially those of hen's egg, have increased since 2017. Twelve of the 18 patients (67%) with egg yolk FPIES achieved tolerance, 50% tolerance at a median age of 27 months.
【Conclusion】In Japan, hen's egg, especially egg yolk, FPIES has recently been increasing. Half of patients with egg yolk FPIES might achieve tolerance by the age of 24 months. We suggest regular oral food challenge tests to avoid unnecessary elimination.
