Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology
Online ISSN : 1882-2738
Print ISSN : 0914-2649
ISSN-L : 0914-2649
What is difference between dietary guidance and oral immunotherapy?
Hajime Nishimoto
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2025 Volume 39 Issue 1 Pages 37-41

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Abstract

What oral immunotherapy and dietary advice have in common is that attending physicians need to clearly dictate the amounts to be eaten and the specific methods while also being responsible for the results. It is reasonable to consider oral immunotherapy as the riskier version of dietary advice. To ensure safety, the loading dose must be set at a safe enough range for the threshold of symptom onset, and guidance and safety measures must be provided for home treatment. If complete elimination is prolonged, the intake of the causative food becomes unnatural, and even if the patient is medically able to eat the food, social and psychological factors may prevent the patient from continuing to eat it, so tolerance cannot be acquired. The attending physician must fight against time and come up with a natural process that avoids complete elimination as soon as possible, allowing the patient to naturally and safely start age-appropriate intake as soon as possible, before the case becomes "a case in which early acquisition of tolerance cannot be expected with a natural process."

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© 2025 Japanese Society of Pediatric Allergy and Clinical Immunology
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