The safety of low-dose peanut oral food challenges in toddlers aged 1-2 years
2025 Volume 39 Issue 2 Pages 142-148
Details
2025 Volume 39 Issue 2 Pages 142-148
Objective: This study evaluated the safety of peanut oral food challenges (OFC) for toddlers aged 1-2 years.
Merhods: From April 2016 to December 2024, the OFCs with loading dose of 0.1 g, 0.2 g and 0.5 g of peanut butter were performed to patients who met at least one of the criteria: Ara h 2-sIgE ≥1.0 UA/mL, a positive result of peanut skin prick test, and a history of allergic reactions after peanut ingestion. The proportions of grade 2 or higher symptoms based on Anaphylaxis guidelines 2022 were evaluated between two groups; toddlers aged 1-2 years and children aged 3-6 years. For more high-risk patients, preliminary OFCs with a total dose of less than 0.1 g of peanut butter were performed.
Results: Sixty-eight patients were evaluated. The proportions of grade 2 symptoms were 24% (6/25) in the 1-2 years group and 28% (12/43) in the 3-6 years group (OR 0.82, 95%CI 0.21 - 2.85, P=0.78). One patient among the 1-2 years group showed an anaphylactic reaction.
Conclusions: The peanut OFC with doses of 0.1 g, 0.2 g and 0.5 g of peanut butter administered to toddlers aged 1-2 years might not be dangerous than those of OFCs to children aged 3-6 years. However, modifications are needed to further enhance safety.
