2025 Volume 39 Issue 5 Pages 384-389
In recent years, the number of patients in Japan with egg yolk-associated FPIES has increased. However, the prognosis and long-term management of egg yolk-associated FPIES have not been established, and the remission time remains uncertain. We retrospectively investigated the timing of remission in 50 patients with egg yolk-associated FPIES who underwent an oral food challenge (OFC) at our hospital between June 2014 and December 2023 based on their medical records. The median age at onset was 8 months; median age at the first OFC for diagnosis or remission confirmation was 15 months; and median ages at the second and third OFC were 23 and 39 months, respectively. Remission was observed in 20 of 50 patients after the first OFC, 4 of 22 after the second, and 2 of 9 after the third. The cumulative remission rates at 24 and 36 months were 35.6% and 51.0%, respectively. Based on the low cumulative remission rate at 24 months, we concluded that it is difficult to achieve early tolerance through the complete removal of egg yolk from the diet. Patients who test positive in the first OFC often test positive in the second and subsequent OFCs as well. Thus, methods for achieving early remission are being sought.
