Abstract
To clarify the effect of the diet in infancy on the development of atopic dermatitis and the production of IgE antibody against mite, 96 babies received varieties of diet were evaluated retrospectively. They were divided into 5 groups. The infants restricted egg from early infancy were divided into 2 groups (group A: showed no food allergy, n=10, group A': showed allergy against some foods, n=14). Eighteen were excluded food (s) that exacerbated symptoms (group B). Thirteen could not avoided the food (s) which worsened their clinical manifestations (group C). Infants showed no exacerbation after ingestion of food were fed unrestricted diet (group D, n=29). The other12 were control infants (group E).
We could not find any difference in the development of atopic dermatitis between group A and D, and between grup A' and B. The dermatitis was significantly severe in group C. About 39% of positive RAST related with the clinical symptoms. The incidence of food allergy was high in infants with RAST scores 3 or more and with more than 3 kinds of positive RAST. The production of IgE antibody against mite was also most frequently detected in those with more than 3 kinds of positive RAST. The incidence of mite allergy was significantly high in group C, and the incidence in group Bwas higher than that in group A'.
In conclusion, the eliminating diet in infancy is effective for the prevention of the development of atopic dermatitis and the production of IgE antibody against mite in children who showed exacerbation of symptoms after ingestion of the food. The ingestion of egg from early infancy was supposed to affect partly the developement of allgic diseasein future.
