Abstract
This study was carried out to prevent the adverse effects to measles vaccine in children with food allergy.
Intradermal skin tests using of diluted measles vaccine were performed in 156 children before vaccination.
The children were divided into two groups: 131 were treated with elimination diet of eggs and/or cow's milk (elimination group) and 25 were treated without elimination diet (non-elimination group).
We examined the association between the positive reaction rate of intradermal skin test (positive rate) and the elimination diet, and examined the correlation between the positive rate and the severity of atopic dermatitis (AD).
The results were as follows:
1) positive rate in elimination group was significantly higher than that in non-elimination group (P<0.01).
2) positive rate was significantly higher in children who had eliminated strictly (P<0.01).
3) positive rate had association with severity of AD at first examination (P<0.05), and had no association at vaccination.
For the children with the positive reaction of intradermal skin test (positive group), we vaccinated with a 1/10 dose of vaccine. We checked the safety and measured the measles antibody titers at 8 weeks after vaccination.
The results were as follows:
4) We observed the adverse effects in all 27 cases: all were slight, none was serious.
5) The measles antibody titers were positive in all 27 cases.
According to these results, we must pay careful attention to the measles vaccination in children with food allergy. We consider it essential that we perform intradermal skin test using measles vaccine on children with food allergy before vaccination and decide on the safe dosage of vaccine.
