Abstract
Prevention of asthma death during adolescence is an important target for pediatric allergists. Here we report a case of asthma death, whose severity had been considered as mild-persistent asthma. He admitted our hospital for cardiopulmonary arrest, and died after 11 days of brain death by acute renal failure. Histology of the lung showed mucus plug, goblet cell hyperplasia, thickness of basement membrane and bronchial smooth muscle, all indicated the presence of chronic bronchial inflammation and remodeling. The patient had consulted two physicians independently, both of whom thought his asthmatic symptoms were successfully controlled by their own prescription. In fact, he had been consuming two or more metered dose inhalers every month, and escaped from hard exercise such as running due to the exercise-induced asthma. Presence of exercise-induced attack should be a point to re-evaluate the severity of asthma and start an adequate anti-inflammatory treatment, even in the patients controlled by overuse of metered dose inhaler.
