Abstract
We examined plasma concentrations of disodium cromoglycate (DSCG) on 6 healthy adults skilled with inhalation therapy using 3 types of nebulizer (NE-U07 as a formal type of ultrasonic nebulizer, NE-U14 as a handy type of ultrasonic nebulizer, and Voyage as a compressed air nebulizer) to estimate differences of drug amounts accessible to the lung among three types of nebulizers. The mean plasma concentration of DSCG by NE-U07 was the highest and that by Voyage was the lowest at any times after inhalation. The mean Area Under the Curve up to 480 min after inhalation was 2197.46min·ng/ml by NE-U07, and 1170.59min·ng/ml by NE-U14, but by Voyage, it was 441.10min·ng/ml, which was lower than that by NE-U07 significantly (p=0.03). Plasma concentration of DSCG exceeded 4ng/ml, which was reported to be more effective to protect asthmatic attacks, in all subjects using NE-U07, in almost half numbers of subjects using NE-U14, but in only one subject using Voyage. We estimated that the amount of DSCG accessible to the lung using ultrasonic nebulizers might be more than that using a compressed air nebulizer. Moreover, the formal type of ultrasonic nebulizer showed the possibility to obtain larger amount of DSCG accessible to the lung than the handy type of ultrasonic nebulizer.
