Abstract
High-dose beclomethasone dipropionate inhaler (BDI) therapy (800-1200μg/day) was carried out for 3 to 10 months to 13 patients (Aged 10 to 15 years) with severe childhood Asthma 1) Clinical improvement appeared after 1 month on high-dose BDI therapy and was seen in all patients after 3 to 10 months. (Marked improvement in 4 cases, moderate improvement in 4 cases and slight improvement in 5 cases). 2) Measurement of serum cortisol levels at 6:00AM and rapid ACTH test showed no significant difference between control group and high-dose BDI group, and between pre and post in high-dose BDI group. 3) Oral candidiasis was not seen in any patients.
It is concluded that high-dose BDI therapy (800-1200μg/day) may be effective on control of severe childhood asthma and has no adrenocortical supperesive effect.
