Abstract
We studied the schedule of oral aminophylline and sustained release theophylline dosing just after ceasing of constant aminophylline infusion. Thirty asthmatic children (twenty boys), ranging in age from 2 to 12 years, who were admitted to the hospital and received constant aminophylline infusion, enrolled in this study.
The result is that oral aminophylline dosing after constant infusion may lead the serum theophylline concentration to the toxic level when the initial level is high and after that serum theophylline concentration decreases rapidly. On the other hand, sustained release theophylline, administered just after or 2 hours after stopped constant aminophylline infusion, exhibited safety and suitable theophylline level. So it is recommended that, if possible, constant aminophylline infusion should be stopped after monitoring serum theophylline level within 2 hours before the time of fixed sustained release theophylline administration.
