Abstract
Sixteen children with idiopathic nephrotic syndrome (INS) were investigated to study the relationship between INS and allergy. The patients were found to have a greater incidence of asthma and allergic rhinitis than the control group. Two children had nasal discharge and asthma attack, related to relapse. In 2 children with INS, proteinuria was reduced by house dust and mite avoidance. Serum total IgE levels in children with INS were significantly higher at both the time of onset and the time of relapse than at the time of remission. It was particulary true in children who were older than six and had atopic disorder and frequent relapses. Moreover, it tended to be higher at the time of remission than the control group. Children with INS had a greater incidence of positive specific IgE antibody against Dermatophagoides farinae, egg and bean.
These results suggest that clinical and immunological features of atopy were more common in children with INS, and allergic factor may be a cause of INS.
