Abstract
Generally the incidence of aspirin-induced asthma (AIA) in adult asthmatics has been reported about 10%. But in children AIA is relatively rare in Japan. Sixty two asthmatic children were admitted to our hospital. Three of them were diagnosed as AIA. Case I was a 16-year-old girl, and diagnosed as AIA by her anamnesis. After avoidance of aspirin and nonsteroidal antiinflammatory drugs and tartrazine, her asthma attacks have remarkablly decreased. Case 2 was a 16-year-old girl, and diagnosed by her anamnesis and positive reaction to inhalation test with Sulpyrin and Venopirin. Case 3 was 12-year-old girl, and severe, intractable and steroid-dependent asthmatic patient. It was suspected that she had suffered from AIA. She was diagnosed by positive reaction to inhalation test.
AIA was characterized by 1) severe and intractable, steroid-dependent, 2) low serum IgE levels with negative allergy skin tests except fungi. Thus in severe and intractable asthmatic children we should consider AIA and conduct examination, then the number of incidences of AIA may increase.
