EFFECT OF ROXITHROMYCIN ON SUPEROXIDE GENERATION BY POLYMORPHONECLEAR LEUKOCYTES FROM CHILDREN WITH BRONCHIAL ASTHMA

Katsumi Takei; Masahiko Kato; Hiroyuki Mochizuki; Kenichi Tokuyama; Akihiro Morikawa; Takayoshi Kuroume; Shozo Maeda

doi:10.3388/jspaci.9.1

Katsumi Takei, Masahiko Kato, Hiroyuki Mochizuki, Kenichi Tokuyama, Akihiro Morikawa, Takayoshi Kuroume, Shozo Maeda

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Keywords: roxiythromycin, superoxide

JOURNAL FREE ACCESS

1995 Volume 9 Issue 1 Pages 1-5

DOI https://doi.org/10.3388/jspaci.9.1

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Abstract

The effect of roxithromycin (RXM) on superoxide (O₂^-) generation was studied in peripheral polymorphonuclear leukocytes (PMN) from children with bronchial asthma. The O₂^- generation activity was investigated using methoxy-cypiridina luciferin analog (MCLA), a specific chemiluminescence (CL) probe for O₂^- RXM suppressed the ability of O₂^- generation at 1×10^-5M, the concentration of clinical use. The level of suppression was different among stimulants to PMN.

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