EVALUATION OF FACTORS TO INFLUENCE TEOHPYLLINE CLEARANCE IN YOUNG CHILDREN WITH ACUTE ASTHMA

Abstract

We evaluated the factors which influenced theophylline clearance during continuous intravenous aminophylline infusion in young athmatic children less than 2 years of age. We examined the relationship between the theophylline clearance and various factors sach as age, sex, body weight, fever, diarrhea and vomiting, in each of four deviled age groups.
We analyzed these relationship using multi variant analysiswith the rate of discrimination of 84%.
Low age (especialy under 6 months old), fever and diarrhea decreased theophylline clearance, but sex, body weight and vomiting were not related to theophylline clearance.
These resalts suggest that the be age, diarrhea and fever should be considered when we start the continuous intravenous aminophylline infusion.