2020 Volume 36 Issue 4 Pages 270-276
Bis-diamine is a potent teratogen in rats, with it inducing cono-truncal diseases and thymic hypoplasia which are similar to chromosome 22q11 deletion syndrome (C22DS) in human. These cardiac cross-sectional anatomies in the fetus with rapid whole-body freezing, cutting with a freezing microtome every 0.5 mm, photographing with photomicroscope (Wild M400) in locking down view were published previously. This reports another two fetuses with tetralogy of Fallot photographed in looking–up view in every 0.25 mm and a fetus with normal heart. 1) has a normal heart with absent thymus, 2) is a heart with tetralogy of Fallot (TOF), severe pulmonary valve stenosis, hypoplastic pulmonary artery, absent ductus arteriosus, single right coronary artery with high take-off and aberrant origin of right subclavian artery, and 3) is a heart with TOF, absent pulmonary valve, and aneurysmally-dilated pulmonary arteries obstructing the trachea, dilated right and left ventricle, increased pericardial effusion, along with a hypoplastic thymus. These color pictures will be instructive for the echocardiographer in examining the fetus with TOF.
