LPS Derived from Aggregatibacter actinomycetemcomitans Inhibits Differentiation and Cell to Cell Communication in Osteoblast

Abstract

Aggregatibacter actinomycetemcomitans (A. a) is frequently associated with aggressive periodontitis in children and adolescence. Although, it is well understood that lipopolysaccharide (LPS) derived from A. a stimulates host-immune system and induces osteocrastic differentiation, the effect of LPS on bone formation and cell to cell communication via gap junction in osteoblast is still unknown.In the present study, we revealed the expressions of mRNA of differentiation markers (alkaline phosphatase, osteocalcin, and bone sialoprotein) and cell-cell communication via gap junction in mouse osteoblast MC3T3-E1 were inhibited remarkably with LPS derived from A. a.