Tooth Anomalies in Child Previously Treated for Neuroblastoma

Abstract

We present here the late effects of combined chemotherapy, radiation therapy, and hematopoietic stem cell transplantation on dental development in a patient treated for neuroblastoma at an early age. A 11-year-11-month old girl came to the University of Tsurumi Dental Hospital with a chief complaint of dental caries. Her medical history revealed that the patient was diagnosed with a stage IV neuroblastoma at the age of 3 years 10 months, for which she had been treated with chemotherapy,tumor resection, radiation therapy (left neck 10 Gy, total body 10 Gy), and hematopoietic stem cell transplantation from the age of 3 years 11 months to 4 years 3 months. In addition, oral 13-cis retinoic acid was administered until 6 years 2 months old. Our oral examination revealed dental caries in multiple teeth, while periapical and panoramic x-ray findings showed morphological anomalies in multiple teeth and hypoplasia of all roots. Remarkable tooth dysplasia, and developmental abnormalities of the maxilla and mandible were suggested to be caused by the combination of chemotherapy, radiation therapy, and hematopoietic stem cell transplantation in this patient.