Abstract
Blood plasma and saliva were analyzed from severely handicapped patients (36 cases) with the administration of Phenytoin (DPH) in an asylum.
One potion of blood plasma was ultrafiltrated with ‘Ultrafree’(Worthington)(free DPH). Saliva was taken from the oral cavity (whole saliva) or from the parotid duct (parotid saliva) with a plastic tube and then the changes of salivaly composition after DPH administration were investigated.
The results were as follows:
1) Both the total and free DPH concentration of blood plasma correlate to the DPH concentration of whole and parotid saliva.
2) Increases of whole salivary calcium and inorganic phosphorus were noticed in the DPH administered group.
3) Both concentration and secretion of salivary calcium and inorganic phosphorus were significantly correlated to the total DPH, free DPH and whole saliva DPH concentration.
4) No correlation between the calcium and inorganic phosphorus and the concentration of DPH was noticed in parotid saliva.
5) These results suggest that the change of concentration of salivary calcium and inorganic phosphorus are reflected by the plasma DPH.
