Abstract
Caries-inducing activity of corn syrup which contains mono- and oligosaccharides, with maltose as its principal constituents, was examined in vitro and in vivo.
In vitro experiments, acid production and insoluble glucan synthesis from corn syrup by Streftococcus mutans were examined. Furtheremore, the effect of corn syrup on synthesis of insoluble glucan by GTase of S. mutans and on the adherence of S. mutans cell to glass surface were assessed in the presence of sucrose.
In vivo experiments, the effect of corn syrup on caries development was examined in SPF Sprague-Dawely rats which had been infected with S. mutans MT8148R (serotype c) or 6715 (g) and fed cries-inducing diet 2000 or diet replacing sucrose to the corn syrup being. tested. The following results were obtained.
1. Corn syrup can be utilized as the substrate for acid production but not for insoluble glucan synthesis by S. mutans.
2. Corn syrup significantly inhibited the insoluble glucan syntheisis from sucrose.
3. Corn syrup was proved to be of low cariogenicity in rats.
