Abstract
A nine year old boy with meylodysplastic syndrome was treated with bone marrow transplantation (BMT) in the Division of Hematology of Chiba Children's Hospital. In the course of the treatment his oral hygiene was observed for 21 months by the dental staff.
The oral management for the BMT patient was divisible into 3 phases. Phase I was prior to BMT, Phase II was a period from the marrow infusion to the recovery of granulocytopenia, and Phase III was long-term follow up after Phase II.
Oral complications in Phase II mainly were gingival bleeding and hyperplasia. A gingival bleeding was observed on the third day after BMT with decreased number of blood platelet. The marked gingival hyperplasia induced by cyclosporine A developed around the region of upper and lower deciduous molars four weeks after BMT.
Over a 21-month period neither tooth infection nor periodontal diseases had occurred. Moreover, herpes virus and Canadida infections were not observed.
