Change in Values of Blood Components with Increasing Age in Rats

Abstract

Hematological investigation is essential to understand the metabolic condition of the living body as it is important to know the normal values of the blood components. Moreover, the values change with increasing age. Therefore, we measured the mean values of blood components of Wistar rats chronologically equivalent to the weaning period, babyfood, school age, the age of puberty, adult age, the prime of life and old age in human beings.
1. Bilirubin showed higher values at the weaning period and the adult age.
2. Total proteins increased with aging.
3. The values of GOT, GPT, LDH, CPK increased with aging and showed higher values at the age of puberty and old age. ALP showed higher values at the weaning period, school age and the age of puberty. γ-GTP showed lower values at the weaning period and showed higher value at school age.
4. Cholesterol showed higher values at the weaning period and old age. The values of triglyceride increased with aging until the adult age and decreased after that.
5. The value of sugar increased with aging until the adult age.
6. BUN and creatinine showed higher values at the weaning period and the age of puberty. Uric acid showed constant values while it showed higher values at the weaning period.
7. Na and Cl showed constant values with aging. K and P showed higher values at the weaning period and decreased after that. Ca showed higher values at the weaning period, the age of puberty and the adult age.
8. C-PTH showed higher values at the age of puberty, the adult age and old age. N-PTH showed higher values at the weaning period. CT showed constant value with aging.1,25(OH)₂VD showed higher values at the weaning period, adult age and the prime of life.