Abstract
To develop a pit and fissure sealant for partially erupting permanent teeth, we produced several trial cements combining tetracalcium phosphate (4CP) and CaF2. We investigated the release of Ca, P, and F from them into distilled water and their remineralizing effect on artificial subsurface lesions in vitro. From 4CP cements, more Ca and P was released than from a glassionomer cement used as the control, while little F was released from even cement combining 4CP and fluoride. Furthermore,4CP cements, whether fluoride was combined or not, promoted the remineralization on artificial subsurface lesions for seven days. The glassionomer cement did not remineralize the artificial subsurface lesion under the cement. These results suggest that the promoting of remineralization by 4CP cements is chiefly due to the Ca and P released from them.
