Abstract
The purpose of this study was to investigate of the factors that influence the clinical effect of the sedation with intranasal administration of midazolam combining nitrous oxide/oxygen inhalation for handicapped patients during dental treatment.
Nineteen mentally handicapped patients, aged 5 to 20 years, all of whom had previously exhibited highly combative and resistant behavior toward dental treatment under nitrous oxide/oxygen inhalation sedation, were administered either 0.2 mg/kg or 0.3 mg/kg intranasal midazolam. The patients then received dental treatment combining nitrous oxide/oxygen inhalation (20-40% N2O/80-60%O2).
They were distributed into two groups. The first group was the effective group of 10 patients with intranasal sedation and the second group was the ineffective group of 9 patients with intranasal sedation. The calendar age, weight, sex, diagnosis of handicap, dose per weight, total volume of dose, time length of dental treatment and developmental age were compared between the two groups. A summary of the results is as follows:
With all factors except the calendar age and diagnosis of the handicap, there were no significant differences between the two groups. The average calendar age of the effective group was 15 years and 10 months, and that of the ineffective group was 10 years and 6 months. There were significant differences between the average calendar ages of the two groups. The ratio of autistic patients in the ineffective group was significantly larger than that in the effective group.
