Abstract
This study investigated the changes of the sedative effect and plasma concentration of midazolam, and the status of the recovery of the walking function, and the influence on blood pressure, heart rate, respiratory rate and oxygen saturation (SPO2) after sublingual administration of midazolam (0.2 mg/kg). The subjects were 8 healthy adult volunteers aged from 19 to 25.
The highest average plasma concentration of midazolam was 71.7 ng/ml at 30 minutes after administration. The initial sedative effect appeared within 10 minutes after administration. A suitable level of sedation was attained at 25 minutes after administration, and that continued until 60 minutes after administration. All of the cases were able to react normally to verbal stimulus and walk normally by 150 minutes after administration.
Blood pressure and oxygen saturation (SPO2) after administration tended to decrease below the control levels (previous to administration). All of these changes were within normal limits. Heart rate and respiratory rate showed no significant changes, compared to the control levels. No major adverse effects appeared during the experimental period. We believe that the decreases in blood pressure and SPO2 were due to the sedative effects of midazolam and this technique is suitable for safety conscious sedation.
