Abstract
Effects of rearing senescence accelerated mice (SAM P-1) with solid and fine-grained diets on general growth, progression of aging, and longevity were studied.
1) No differences were noted in body weight and diet consumption in the two groups.
2) The score was always higher in the fine-grain-diet group than in the solid-diet group, and the difference increased with advancing age.
3) Spontaneous locomotor activity attained its peak level in the 15 th week in the solid-diet group, and in the 12th week in the fine-grain-diet group, and decreased gradually thereafter. Activity was always lower in the fine-grain-diet group than that in the solid-diet group.
4) No amiloid deposition in the tongue was noted in the 4th week. In the 24th and 52nd weeks, it was higher in the fine-grain-diet group than in the solid-diet group.
5) Mice in the fine-grain-diet group tended to die earlier.
The present results suggest that the aging process progresses more quickly, and longevity is shortened by rearing the SAM P 1 mice with the fine-grained diet, as compared with the solid diet.
