Abstract
Disturbances in dental development were reported in an 8-year-8-month-old girl with neuroblastoma who had been treated with chemotherapy at an early age.
The patient was diagnosed at the age of 2 years with neuroblastoma (Stage IV A). She was treated with a high dose of chemotherapy between 2-years and 2-years-9-months of age. After chemotherapy, she underwent a surgical resection of the tumor and an autologous bone marrow transplantation. She never underwent a total body irradiation, however.
All of the first premolars were reduced to the microdontia although the other erupted teeth exhibited normal crown size. Panoramic and dental radiographs, taken at the age of 8 years and 8 months, showed other multiple teeth anomalies. All of the second premolars and the lower right second molar were absent. The incisors, canines, first premolars and first molars exhibited short tapered roots and premature apical closure.
These findings indicate that a high dose of chemotherapy may result in a higher prevalence of various malformation of the teeth.
