Abstract
Down's syndrome is a chromosome abnormality with a high frequency. It is possible that different dental materials have different toxicities, but there is no basic data on which to choose between them. We, therefore, examined the cytotoxicity of five commercial dental cement liquids on fibroblast-like Down's syndrome cells (Detroit 539). We compared the IC 50 values of the Detroit 539 and fibroblast-like normal human cells (HUC-F). Cytotoxicity was evaluated using the MTT test. As for the Detroit 539 cells, the cytotoxicity of four kinds of luching cement liquids were lower than the HUC-F cells. The IC 50 of Detroit 539 cells in particular declined at the a resin modified glassionomer cement. Futher testing with defferent kinds of dental materials is required.
