Abstract
In this study, the role of CPP-ACP (casein phosphopeptide-amorphous calcium phosphate) containing paste (MI paste®, GC, Japan) on caries prevention was determined in a pH cycling experiment of de/remineralization.
To evaluate the effects of CPP-ACP containing paste on promoting remineralization, bovine enamel slabs were immersed in 0.01% sodium fluoride (NaF) solution conditioned in the presence of CPPACP with/without xylitol for 0.5 hour and then each specimen was stored in demineralizing solution (0.1 M lactic acid buffer solution,1 mM CaCl2,0.6 mM KH2PO4: pH 5.3) for 23.5 hours. This process was repeated once a day for 4 days.
The results were as follows:
1. By the action of CPP-ACP, it has kept enamel surface intact in the demineralizing solution, and moreover with the presence of xylitol, this situation was showed to promote remineralization in the mid to bottom of affected enamel area.
2. In the presence of xylitol without CPP-ACP, little effect was observed on the enamel surface whereas remineralization was seen in the mid to bottom area of the demineralized enamel.
3. In the presence of CPP-ACP without xylitol, however the maintenance effect of the enamel surface was seen clearly, the remineralization of enamel inside was seen slightly, and so the mineral loss values were evaluated highly.
These results suggest that MI paste® has the ability to maintain the enamel surface by CPP-ACP and to promote remineralization of the enamel inside by xylitol. The application of MI paste® with fluoride on the enamel surface is considered to play an effectual role in caries prevention.
