2017 Volume 32 Issue 1 Pages 865-870
The aim of this study was to evaluate the effect of synbiotics administration for digestive system side effects in patients treated with chemotherapy.
Eighteen patients with primary lung, gastric, and colon cancer treated with chemotherapy were allocated to the two groups; one group (9 patients) received synbiotics before and during chemotherapy, and the other (9 patients) did not. The frequency of digestive symptoms, compliance with chemotherapy, weight, dietary intake and plasma diamine oxidase (DAO) activity were assessed.
Patients in the synbiotics group showed less in anorexia (grade 2 or higher, p = 0.041). Furthermore, decrease in DAO activity was less, body weight was maintained (p = 0.048) and chemotherapy dosage was kept in the synbiotics group.
In conclusion, synbiotics administration in patients treated with chemotherapy may be less in anorexia and maintain ideal body weight as well as compliance with chemotherapy.
