2017 Volume 32 Issue 3 Pages 1154-1161
Objective: We paid attention to a cancer taking in a lot of glucose, introduced the ketogenic diet of a severe carbohydrate intake restricting and examined the safety and effect of the chemotherapy combination.
Methods: We got approval of an ethics review board of our hospital and made the modified MCT ketogenic diet of ketones ratio 1.5-1:1 taken in for advanced colorectal cancer and breast cancer of stage IV for three months. We examined a metabolism, a nutrition, QOL and clinical effects against cancer.
Results: We examined nine patients. The non-diabetic mellitus patients suffered from ketosis by ketogenic diet, and suffer from mild acidosis by urinary excretion. The patients were accompanied by a significant decrease in 5.4% of weight loss, but the liver and the renal function was kept. The patients did not have a reduction in quality of life by the combination with the chemotherapy either. Response rate was 67 %, disease control rate was 78%. It was suggested that the effect of treatment correlated with a blood ketone body level and quality of life score.
Conclusion: The modified MCT ketogenic diet with the chemotherapy for 3 months was a safe diet in patients with cancer of stage IV, and it was suggested that the reduction of cancer was associated with blood ketone body level and quality of life score.
