Four cases of thyroid carcinoma after treatment for malignancy in childhood

Abstract

We report four cases of thyroid carcinoma occurring in patients who had been treated for malignancy in childhood. The initial malignant neoplasms were anaplastic sarcoma of the kidney, atypical teratoid/rhabdoid tumor, pleuropulmonary blastoma, and yolk sac tumor. All the patients had undergone surgery and received adjuvant chemotherapy. Two patients had received radiation therapy that included the neck in one patient. The interval between treatment and diagnosis of thyroid carcinoma ranged from 4.3 to 8.8 years (median 7.5 years). Histopathological diagnoses included one papillary carcinoma and three follicular carcinomas. Long-term follow-up with thyroid palpation and ultrasound is recommended for childhood cancer survivors.